Nalbandian was born on November 14, 1829, in Nor Nakhichevan, the town close to Rostov-on-Don founded in the late eighteenth century by Armenian emigrants from Crimea, in the family of a craftsman. He studied in his hometown at the school of Gabriel Patkanian, and for a while he was classmate of his son, the future poet Rafael Patkanian (Kamar Katipa).